BioOne.org will be down briefly for maintenance on 13 August 2025 between 18:00-21:00 Pacific Time US. We apologize for any inconvenience.
How to translate text using browser tools
1 July 2001 Thyroid Cancer after Diagnostic Administration of Iodine-131 in Childhood
Klaus Hahn, Petra Schnell-Inderst, Bernd Grosche, Lars-Erik Holm
Author Affiliations +
Abstract

Hahn, K., Schnell-Inderst, P., Grosche, B. and Holm, L-E. Thyroid Cancer after Diagnostic Administration of Iodine-131 in Childhood. Radiat. Res. 156, 61–70 (2001).

To determine the carcinogenic effects of diagnostic amounts of 131I on the juvenile thyroid gland, a multicenter retrospective cohort study was conducted on 4,973 subjects who either had been referred for diagnostic tests using uptake of 131I (n = 2,262) or had had a diagnostic procedure on the thyroid without 131I (n = 2,711) before the age of 18 years. Follow-up examinations were conducted after a mean period of 20 years after the first examination in 35% of the exposed subjects (n = 789) and in 41% of the nonexposed subjects (n = 1,118). Iodine-131 dosimetry of the thyroid was carried out according to ICRP Report No 53, and the median thyroid dose was 1.0 Gy. In the exposed group, two thyroid cancers were found during 16,500 person-years, compared to three cancers in the nonexposed group during 21,000 person-years. The relative risk for the exposed group was 0.86 (95% CI: 0.14–5.13). The study did not demonstrate an increased risk for thyroid cancer after administration of 131I in childhood.

Klaus Hahn, Petra Schnell-Inderst, Bernd Grosche, and Lars-Erik Holm "Thyroid Cancer after Diagnostic Administration of Iodine-131 in Childhood," Radiation Research 156(1), 61-70, (1 July 2001). https://doi.org/10.1667/0033-7587(2001)156[0061:TCADAO]2.0.CO;2
Received: 8 August 2000; Accepted: 1 February 2001; Published: 1 July 2001
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top